Day four transfers, or transfers at the morula stage, are fairly new and not used by many centers today. Researching day 4 transfers and their similarity to the natural process is a main goal of this study. The majorities of IVF clinics either do early cleavage transfers on day 2 or 3, or extended culture for a blastocyst transfer on day 5 or 6. There are very few centers today that actually perform embryo transfers on day 4, and little research has been done on this subject.
Day 4 embryo transfers have a benefit of a better selection of embryos than in day 2 or 3, while avoiding the vulnerability of extended embryo culture associated with culturing embryos to day 5 and 6. Day four transfers also most accurately reflect the natural process and provide an optimal condition for assisted hatching. Day four transfers appear to be beneficial to both the patient and the IVF clinic. If indeed day four transfers produce encouraging results, they are also a way to reduce the need for staff working on the weekends. Day 3 transfers that fall on a Sunday can then be pushed back to Monday for a day 4 transfer. There are very few IVF clinics today that actually perform embryo transfers on day 4, and little research has been done on the subject. It is surprising that the study of day four transfers have been neglected.
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