The resulting risk factor calculated at 6.4% does not corroborate the theory for familial liability of upper urinary tract infections. In fact if a margin of error for the calculation is taken into account the number would be lower as well. The risk factor would further decrease if taken into account that a certain number of the parents had been diagnosed as having a broadly defined form of psychosis. Such a familial history of psychosis has been proven to be an important etiological factor for the incidence of schizophrenia and further show the fallibility of the author’s contentions.
While the study is purported to use environmental factors as a reason for the incidence of schizophrenia in patients it does not take into account that there may be other factors in play here which may have induce such psychotic episodes. Other studies which have attempted to compare the effects of first and second generation antipsychotics on schizophrenics have found that there are a variety of environmental factors which can increase the incidence of the disease and the outcome of the studies including but not limited to acute symptoms, substance abuse and other co-morbidities, lack of quality of life. These studies have admitted that the incidences of these factors are key in the measurement of the outcome of not only the incidence of the disease but also the effectiveness of the medication prescribed. They admit however, that such measures and real world clinical practice cannot always be taken into account (Altamura & Glick, 2010). In the case of this research study this point of contention particularly holds true as the data on the clinical practices employed, as well as antibiotic therapy are simply not available in order to exclude a viable cause.
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