For  the  purposes of  this  study the objective  was quantify the benefits and harms of adding clopidogrel  to standard long term aspirin  therapy for preventing cardiovascular events in people at high risk cardiovascular diseases and those with established  cardiovascular  diseases.

Randomized control trials to compare long-term use of aspirin plus clopidogrel with aspirin plus placebo for the patients described above were included with a follow up of up to 30days. The study involved aspirin plus clopidogrel versus aspirin plus placebo or aspirin alone. No other platelet aggregation inhibitors as co-intervention were accepted.

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